Endometrial Cancers From Tamoxifen Are Not More Aggressive
نویسندگان
چکیده
منابع مشابه
Tamoxifen and Endometrial Cancer.
Tamoxifen is commonly used in the management of patients with breast cancer. Clinical trials of tamoxifen involving over 75,000 patients demonstrate an improved recurrence-free and overall survival benefit in both pre- and post-menopausal women. Large-scale trials also are evaluating the role of tamoxifen as a chemopreventive agent in women considered to be at high risk for developing breast ca...
متن کاملEndometrial pathology of tamoxifen
very small vessels resulting from neovascularization explain why the patient experiences hemorrhaging. Neovascularization is an essential part of the definition of a poiyp. Polyps in themselves do not present a risk for the patient but they result in a decrease in compliance to treatment as a result of the hemorrhaging. Hyperplasia without atypia generally occurs in patients who do not comply w...
متن کاملAre rapidly growing cancers more lethal?
The view, that rapidly growing tumours are more likely than slow-growing tumours to metastasize and become lethal, has remained almost axiomatic for decades. Unaware of any solid evidence supporting this view, we undertook an exhaustive system-level analysis of intra- and intercellular signalling networks. This analysis indicated that rapid growth and metastasis are often different outcomes of ...
متن کاملLkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy.
Endometrial cancer--the most common malignancy of the female reproductive tract--arises from the specialized epithelial cells that line the inner surface of the uterus. Although significant advances have been made in our understanding of this disease in recent years, one significant limitation has been the lack of a diverse genetic toolkit for the generation of mouse models. We identified a nov...
متن کاملHypoxic cervical cancers with low apoptotic index are highly aggressive.
There is evidence from experimental work that hypoxia induces apoptosis in apoptosis-sensitive neoplastic cells and that this apoptotic sensitivity is lost during malignant progression. Oxygenation profiles and apoptotic indices in human squamous cell cancer of the uterine cervix have been determined, and a subgroup of tumors has been identified with low apoptotic index despite pronounced hypox...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 1996
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/88.16.1101